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GIOTRIF® vs gefitinib for 1st-line treatment of EGFRm+ NSCLC

14/07/2024 | Author: Boehringer Ingelheim
Document ID: PC-MY-101861

2nd-generation EGFR-TKIs differ from the 1st-generation inhibitors (or EGFR-TKIs) in their mechanism of action, with the former having broad spectrum activity and irreversible binding to EGFR receptors, which may result in an improved inhibition of tumour growth. The LUX-Lung 7 trial evaluated the efficacy of 1st-line GIOTRIF® vs gefitinib in patients with common EGFR mutations.4

GIOTRIF® provided faster and improved objective response vs gefitinib4

  • The proportion of patients who achieved an objective response was significantly higher with GIOTRIF® vs gefitinib (70% vs 56%; OR: 1.87 [95% CI: 1.18-2.99]; p=0.0083)

  • Tumour shrinkage was observed as early as week 4 with a difference between the two arms.4

GIOTRIF® demonstrates deeper tumour shrinkage vs gefitinib in L858R patients4

  • The proportion of patients achieving an objective response with GIOTRIF® was more pronounced in patients with L858R mutations4

  • A larger proportion of patients exhibited a ≥50% consistent decrease in tumour size with GIOTRIF® compared to gefitinib (39% vs 21%)4

Efficacy

RWDRI||Vietnam RWD 2024
RWDRI||Real-World First-Line GIOTRIF® for EGFRM+ NSCLC: Updated Survival Data from Korea
MYGIO2022COM||GIOTRIF® provides ≥3 years long-term response even with dose modification
MYBIONEGIO2022||South Korean Dataset: Frontline Giotrif in Uncommon EGFR Mutations
SEREAL||First-line GIOTRIF® data in over 30 real-world studies to-date
GIOTRIF® safety and effectiveness in the real world
Real-world evidence: GIOTRIF® in Japan
MYSEREAL||Real-world evidence: GIOTRIF® in Taiwan
Real-world evidence: GIOTRIF® in South Korea
SEREAL||GIOTRIF® Uncommon EGFR pooled analysis in 693 patients
MYGIO2022COM||GIOTRIF® vs gefitinib for 1st-line treatment of EGFRm+ NSCLC
RWDRI||Real-World Effectiveness of GIOTRIF® vs Osimertinib - Data from Japan
RWDRI||Real-World Effectiveness of GIOTRIF® on Brain Metastases – Data from Korea and Taiwan
SEREAL||GIOTRIF® RWE in patients with brain metastases
SEREAL||Impact of GIOTRIF® in delaying CNS progression
SEREAL||GIOTRIF® RWE in Taiwan
SEREAL||GIOTRIF® efficacy in the real-world
SEREAL||GIOTRIF® in LUX-Lung 7
MYGIO2022COM||GIOTRIF® in elderly
MYBIONEGIO2022||GIOTRIF® in uncommon EGFR mutations
RWDRI||GIOTRIF® in Uncommon Mutation - A database analysis of >1000 NSCLC Patients

References

1. Sequist LV et al. J Clin Oncol. 2013;31(27):3327-3334.

2. Wu YL et al. Lancet Oncol. 2014;15(2):213-22.

3. Yang JC et al. Lancet Oncol. 2015;16(2):141-51.

4. Park K et al. Lancet Oncol 2016;17(5):577–89.

Footnotes

  • CI = confidence interval; EGFR M+=epidermal growth factor receptor mutation positive; EGFR-TKI = epidermal growth factor receptor tyrosine kinase inhibitor; IQR = inter-quartile range; NSCLC=non-small cell lung cancer; PFS=progression-free survival; ORR = objective response rate; OR =odds ratio; OS=overall survival; CI = confidence interval; IQR = inter-quartile range

  • * LUX-Lung 3 (vs pemetrexed/cisplatin) and LUX-Lung 6 (vs gemcitabine/cisplatin): superior PFS (primary endpoint) and superior OS in Del19 subgroup (secondary endpoint); LUX-Lung 7 (vs gefitinib): superior PFS (primary endpoint).

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